"Lucky" Luciano gains power in the New York underworld during Prohibition. When two bosses start a mob war, Luciano plans to kill them both.

"Lucky" Luciano takes over the New York mob, organizing the Five Families. As Luciano's power grows, so does the attention from the Feds.

Luciano's decision to enter the prostitution business gives Thomas Dewey the chance to arrest him and put him on trial.

Luciano is found guilty of running a prostitution ring and goes to prison, leaving Vito Genovese as acting boss.

World War II begins, and the military asks Luciano to aid in the invasion of Sicily. Thomas Dewey considers letting him go.

Luciano takes over Vito Genovese's heroin ring in Italy, then rejoins Meyer Lansky at a mob summit in Cuba. Genovese and Carlo Gambino plot against the mob leadership, and Bugsy Siegel's dream of Las Vegas turns deadly.

Vito Genovese and Carlo Gambino make their move. The police raid a mob summit, arresting Genovese. Gambino takes over.